NEDD4: A Promising Drug Target for Neurodegenerative Diseases

Target Name: NEDD4

NCBI ID: G4734

NEDD4

NEDD4: A Promising Drug Target for Neurodegenerative Diseases

NEDD4 (NEDD-4), a protein that plays a critical role in the development and progression of neurodegenerative diseases, has emerged as a promising drug target and biomarker. Its function in the immune system and its interaction with other proteins have been studied extensively in recent years, and its potential as a therapeutic agent is under investigation.

The neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are progressive disorders that affect the brain and cause a range of symptoms, including cognitive decline, motor dysfunction, and decline in quality of life. These conditions are typically progressive and have no known cure, making them a significant public health burden.

NEDD4 is a protein that is expressed in the brain and plays a crucial role in the development and progression of neurodegenerative diseases. Its function in the immune system and its interaction with other proteins have been studied extensively in recent years, and its potential as a therapeutic agent is under investigation.

One of the key functions of NEDD4 is its role in the immune system. NEDD4 is a key regulator of the immune response, and its absence has been linked to an increased risk of developing neurodegenerative diseases. Additionally, NEDD4 has been shown to play a role in the regulation of neuroimmune homeostasis, which is the balance between the activity of the immune system and the protection of the brain.

Another important function of NEDD4 is its role in the development and progression of neurodegenerative diseases. NEDD4 has been shown to be involved in the development of neurofibrillary tangles, which are a hallmark of neurodegenerative diseases, as well as in the regulation of neurotransmitter homeostasis, which is the balance between the levels of neurotransmitters in the brain and their effects on the brain.

In addition to its role in the immune system and neurodegenerative diseases, NEDD4 has also been shown to play a role in the regulation of inflammation. NEDD4 has been shown to play a role in the regulation of the immune response and has been shown to have anti-inflammatory effects.

Given its potential role in the immune system, NEDD4 has been targeted by researchers as a drug target. Studies have shown that NEDD4 can be modulated with small molecules, such as those derived from natural products, and that these modifications can have a significant impact on the activity of NEDD4. Additionally, NEDD4 has been shown to be a good biomarker for tracking the progression of neurodegenerative diseases, making it an attractive target for clinical trials.

In conclusion, NEDD4 is a protein that plays a critical role in the development and progression of neurodegenerative diseases. Its function in the immune system and its interaction with other proteins have been studied extensively in recent years, and its potential as a therapeutic agent is under investigation. As research continues to advance, NEDD4 is expected to become a valuable tool for the development of new treatments for neurodegenerative diseases.

Protein Name: NEDD4 E3 Ubiquitin Protein Ligase

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597, PubMed:21399620, PubMed:19920177). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177)

The "NEDD4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NEDD4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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