NECTIN4: Role in Cell Adhesion, Growth and Differentiation, Cell Death and Immune Response

Target Name: NECTIN4

NCBI ID: G81607

NECTIN4

NECTIN4: Role in Cell Adhesion, Growth and Differentiation, Cell Death and Immune Response

Nectin cell adhesion molecule 4 (NECTIN4) is a protein that is expressed in various tissues and cell types in the human body. It is a member of the cadherin family of transmembrane proteins, which are involved in cell-cell adhesion and tissue organization. NECTIN4 is characterized by its unique structure, which consists of a long N-terminus, a middle transmembrane region, and a C-terminus that is involved in cell adhesion.

NECTIN4 is involved in many different processes in the body, including the development and maintenance of tissues and organs, as well as the regulation of cell growth and differentiation. It is also involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. This is an essential process that is necessary for the development and maintenance of tissues and organs, as well as for the formation of tissues such as blood vessels and the nervous system.

One of the key functions of NECTIN4 is its role in cell adhesion. NECTIN4 is involved in the formation of tight junctions, which are the weakest type of cell adhesion. These junctions are responsible for maintaining the integrity of tissues and organs, as well as allowing them to function properly. NECTIN4 is also involved in the formation of adherens junctions, which are stronger types of cell adhesion that are responsible for the formation of tissues such as epithelial tissues and the lining of various body surfaces.

In addition to its role in cell adhesion, NECTIN4 is also involved in the regulation of cell growth and differentiation. It is a negative regulator of cell growth, which means that it works to prevent cells from growing too quickly. This is important for the development and maintenance of tissues and organs, as well as for the regulation of normal cell growth and differentiation.

NECTIN4 is also involved in the regulation of cell death. It is a positive regulator of cell death, which means that it works to promote the programmed cell death that is necessary for the development and maintenance of tissues and organs. This is important for the regulation of tissue homeostasis and for the prevention of diseases such as cancer.

NECTIN4 is also involved in the regulation of the immune response. It is a co-factor for the immune receptor PD-1, which is involved in the regulation of cell growth and differentiation. This means that NECTIN4 plays a role in the development and regulation of immune cells, including T cells and natural killer cells.

In conclusion, NECTIN4 is a protein that is involved in a wide range of processes in the body. Its role in cell adhesion, growth and differentiation, as well as its involvement in the regulation of cell death and the immune response make it a potential drug target or biomarker. Further studies are needed to fully understand the role of NECTIN4 in these processes and to develop new treatments for diseases associated with these processes.

Protein Name: Nectin Cell Adhesion Molecule 4

Functions: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells

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•   general information;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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