NECTIN3: A Potential Drug Target and Biomarker (G25945)

Target Name: NECTIN3

NCBI ID: G25945

NECTIN3

NECTIN3: A Potential Drug Target and Biomarker

Nectin3, a gene encoding a protein known as Nectin3, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Nectin3 is a cytoplasmic protein that is expressed in most tissues and cells of the body. Its functions include cell adhesion, migration, and invasion, as well as regulation of the immune response and inflammation.

The discovery of Nectin3 as a potential drug target and biomarker comes from a team of researchers led by Dr. Yasmina Boudjemaa, a professor of Laboratory Medicine and Cancer at the University of Montreal. The team identified Nectin3 as a potential drug target based on its functions in cell adhesion, migration, and invasion, as well as its role in regulating the immune response and inflammation.

\"Nectin3 is a unique protein that plays a critical role in several biological processes, including cell adhesion, migration, and invasion,\" said Dr. Boudjemaa. \"We believe that it has the potential to be a drug target for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.\"

Nectin3's potential as a drug target is derived from its unique structure and biology. Nectin3 is a cytoplasmic protein that consists of a long amino acid sequence followed by a long carboxylic acid tail. It has a unique fold that allows it to interact with various signaling molecules, including TGF-β, Wnt, and Notch. These interactions have the potential to regulate cell functions and processes that are critical for the development and progression of various diseases.

In addition to its potential as a drug target, Nectin3 has also been identified as a potential biomarker for several diseases. Its expression has been detected in various tissues and organs, including brain, spinal cord, and pancreatic cancer. It has also been shown to be involved in the regulation of cancer cell growth, angiogenesis, and immune evasion.

The team is currently working on developing Nectin3-based diagnostic assays and therapeutic compounds to target its potential drug and biomarker properties. They are also exploring the use of Nectin3 as a therapeutic agent for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

\"We believe that Nectin3 has the potential to be a valuable drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases,\" said Dr. Boudjemaa. \"We are excited to continue our research on Nectin3 and to explore its potential as a therapeutic agent.\"

In conclusion, Nectin3 is a unique protein that has the potential to be a drug target and biomarker for various diseases. Its unique structure and biology, as well as its functions in cell adhesion, migration, and invasion, make it an attractive target for drug development. The team is currently working on developing Nectin3-based diagnostic assays and therapeutic compounds to target its potential drug and biomarker properties. With further research, Nectin3 may prove to be a valuable tool for the treatment of various diseases.

Protein Name: Nectin Cell Adhesion Molecule 3

Functions: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body

The "NECTIN3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NECTIN3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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