Target Name: WDR41
NCBI ID: G55255
Review Report on WDR41 Target / Biomarker Content of Review Report on WDR41 Target / Biomarker
WDR41
Other Name(s): OTTHUMP00000128362 | MSTP048 | WD repeat-containing protein 41 isoform X1 | OTTHUMP00000222209 | OTTHUMP00000222207 | WD repeat-containing protein 41 | WDR41_HUMAN | WD repeat domain 41 | FLJ10904

WDR41: A Potential Drug Target and Biomarker

WDR41 (Wiskott-Aldrich receptor 41) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. WDR41 is a key regulator of hematopoietic stem cell (HSC) self-renewal and has been implicated in the development and maintenance of various diseases, including cancer. The identification of WDR41 as a potential drug target has significant implications for the development of new treatments for these diseases.

WDR41 Structure and Function

WDR41 is a small non-coding RNA molecule that is expressed in a variety of tissues, including blood cells, tissues, and organs. It is characterized by a unique open-loop structure that consists of a 19-amino acid residue, a double-stranded RNA molecule, and a single-stranded RNA molecule. The double-stranded RNA molecule is composed of two sub-units that are held together by a disulfide bond.

WDR41 functions as a negative regulator of the expression of its target genes. It interacts with the RNA polymerase II (RPNI-2) to prevent the translation of certain genes into proteins. This interaction between WDR41 and RPNI-2 provides a level of control over gene expression that is critical for the development and maintenance of tissues and organs.

WDR41 and Cancer

WDR41 has been implicated in the development and progression of various cancers, including breast, ovarian, and colorectal cancers. Studies have shown that high levels of WDR41 expression are associated with the development of cancer and that inhibition of WDR41 has anticancer effects.

One of the potential mechanisms by which WDR41 contributes to cancer development is by regulating the expression of genes that are involved in cell growth and division. WDR41 has been shown to interact with the oncogene transforming growth factor-beta (TGF-beta), which is a key regulator of cell growth and division. By interacting with TGF-beta, WDR41 has been shown to prevent its inhibition of the negative regulator of TGF-beta, which is important for cell growth and division.

Another potential mechanism by which WDR41 contributes to cancer development is by regulating the expression of genes involved in cell survival. WDR41 has been shown to interact with the tumor suppressor gene p53, which is responsible for preventing the development of cancer. By interacting with p53, WDR41 has been shown to prevent its inhibition and enhance its expression, which is important for cancer development.

WDR41 and Disease

WDR41 has also been implicated in the development and progression of various diseases, including autoimmune diseases, neurodegenerative diseases, and respiratory diseases.

One of the potential mechanisms by which WDR41 contributes to the development and progression of autoimmune diseases is by regulating the expression of genes involved in immune responses. WDR41 has been shown to interact with the immune system molecule interleukin-1 (IL-1), which is involved in the regulation of immune responses. By interacting with IL-1, WDR41 has been shown to prevent its inhibition and enhance its expression, which is important for the development and progression of autoimmune diseases.

Another potential mechanism by which WDR41 contributes to the development and progression of neurodegenerative diseases is by regulating the expression of genes involved in neurotransmission. WDR41 has been shown to interact with the neurotransmitter receptor GABA, which is involved in neurotransmission. By interacting with GABA, WDR41 has been shown to prevent its inhibition and enhance its expression, which is important for the development and progression of neurodegenerative diseases.

WDR41 also

Protein Name: WD Repeat Domain 41

Functions: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292)

The "WDR41 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR41 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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