Target Name: WDR24
NCBI ID: G84219
Review Report on WDR24 Target / Biomarker Content of Review Report on WDR24 Target / Biomarker
WDR24
Other Name(s): C16orf21 | WD repeat-containing protein 24 | WDR24_HUMAN | JFP7 | DKFZp434F054 | WD repeat domain 24 | GATOR complex protein WDR24

WDR24: A Potential Drug Target for Neurodegenerative Disorders and Chronic Pain

WDR24 (C16orf21) is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique genetic mutation has led to a gain of function in the gene, resulting in the production of a hyperactive form of the protein.

The WDR24 gene is located on chromosome 16 and encodes for the WD repeat protein 24. This protein is a key component of the WD repeat family, which is characterized by the repeated amino acid sequence Asp-Glu-Asp. The WD repeat protein is involved in various cellular processes, including cell signaling, chromatin structure, and stress response.

WDR24 has been shown to be involved in the development and progression of various diseases. For example, studies have shown that high levels of WDR24 are associated with an increased risk of developing cancer, neurodegenerative disorders, and autoimmune diseases. Additionally, research has suggested that WDR24 may play a role in the development of certain diseases, such as ALS and multiple sclerosis.

The potential drug target for WDR24 is based on its role in the development of neurodegenerative disorders. neurodegenerative disorders are a group of diseases that are characterized by the progressive loss of neural cells and their associated symptoms. These disorders include Alzheimer's disease, Parkinson's disease, and Huntington's disease.

WDR24 has been shown to be involved in the development and progression of neurodegenerative disorders by increasing the production of reactive oxygen species (ROS) in the brain. ROS are free radicals that can damage cellular components and contribute to the development of neurodegenerative disorders.

In addition to its role in the development of neurodegenerative disorders, WDR24 has also been shown to be involved in the regulation of pain. Chronic pain is a common problem that affects millions of people worldwide and can have a significant impact on quality of life.

Research has suggested that WDR24 may play a role in the regulation of pain by modulating the activity of pain-sensitive neurons. Additionally, studies have shown that high levels of WDR24 are associated with increased pain sensitivity, which may contribute to the development of chronic pain.

The potential drug target for WDR24 is based on its role in the development and progression of neurodegenerative disorders and its involvement in pain regulation. Drugs that target WDR24 have the potential to treat neurodegenerative disorders and alleviate chronic pain.

In conclusion, WDR24 is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique genetic mutation has led to the production of a hyperactive form of the protein, which is involved in various cellular processes and is involved in the development and progression of various diseases. Further research is needed to understand the full role of WDR24 in disease and to develop effective treatments.

Protein Name: WD Repeat Domain 24

Functions: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823)

The "WDR24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A