WDR4 as A Potential Drug Target for Various Diseases (G10785)
WDR4 as A Potential Drug Target for Various Diseases
WDR4 (Wdr4) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. WDR4 is a key regulator of gene expression in the Wnt/Wedmore gene family, which is involved in the development and maintenance of various tissues and organs.
The Wnt/Wedmore gene family is a highly conserved group of genes that are involved in the development and maintenance of tissues that play critical roles in development and growth. The genes in this family are involved in the formation of the neural tube, which develops into the brain and spinal cord, as well as the development of other tissues such as the heart, limbs, and eyes.
WDR4 is a non-coding RNA molecule that has been shown to play a key role in the regulation of gene expression in the Wnt/Wedmore gene family. WDR4 is expressed in a variety of tissues and cells and has been shown to be involved in the regulation of cell proliferation, differentiation, and survival.
One of the key functions of WDR4 is its role in the regulation of stem cell proliferation. WDR4 has been shown to play a key role in the self-renewal and differentiation of stem cells, which are cells that have the ability to generate a variety of different cell types. This function of WDR4 is important for the development and maintenance of tissues and organs, including the brain and spinal cord.
In addition to its role in stem cell biology, WDR4 has also been shown to be involved in the regulation of cell survival. WDR4 has been shown to play a key role in the regulation of cell survival by promoting the expression of genes that are involved in cell stress response and apoptosis. This function of WDR4 is important for the regulation of cellular homeostasis and for the prevention of cell death.
WDR4 has also been shown to be involved in the regulation of tissue development and regeneration. WDR4 has been shown to play a key role in the regulation of tissue development and regeneration by promoting the expression of genes that are involved in cell proliferation and differentiation. This function of WDR4 is important for the development and maintenance of tissues and organs, including the brain and spinal cord.
In conclusion, WDR4 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases. WDR4's role in the regulation of gene expression in the Wnt/Wedmore gene family, as well as its functions in stem cell biology, cell survival, and tissue development and regeneration, make it an attractive target for research and clinical development. Further research is needed to fully understand the mechanisms of WDR4's function in these processes and to develop safe and effective drugs that can target WDR4 to treat various diseases.
Protein Name: WD Repeat Domain 4
Functions: Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083, PubMed:36599982, PubMed:36599985). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352207, PubMed:34352206, PubMed:36599982, PubMed:36599985). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069)
The "WDR4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR4 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73
