Target Name: IL17RC
NCBI ID: G84818
Review Report on IL17RC Target / Biomarker Content of Review Report on IL17RC Target / Biomarker
IL17RC
Other Name(s): IL17F receptor | Interleukin 17 receptor C, transcript variant 4 | Interleukin-17 receptor C isoform 2 precursor (isoform 2) | Interleukin 17 receptor C, transcript variant 2 | Interleukin 17 receptor-like | interleukin-17 receptor homolog | IL-17RL | Interleukin-17 receptor C isoform 3 precursor (isoform 3) | I17RC_HUMAN | IL17RC variant 4 | Interleukin-17 receptor homolog | Interleukin-17 receptor C isoform 5 precursor (isoform 5) | MGC10763 | ZcytoR14 | IL17RC variant 2 | Interleukin-17 receptor C isoform 1 precursor (isoform 1) | IL17Rhom | Interleukin 17 receptor C, transcript variant 1 | Interleukin 17 receptor C, transcript variant 3 | zcytoR14 | interleukin 17 receptor C | interleukin-17 receptor-like protein | IL17RC variant 3 | CANDF9 | IL-17 receptor C | IL17-RL | IL17RL | Interleukin 17 receptor C, transcript variant 5 | IL-17RC | IL17RC variant 1 | IL17RC variant 5 | Interleukin-17 receptor-like protein | Interleukin-17 receptor C | Interleukin-17 receptor C isoform 4 precursor (isoform 4)

IL17 Receptor: A Potential Drug Target for Immune and Inflammatory Diseases

The IL17 receptor, also known as IL17F receptor, is a protein that is expressed in a variety of tissues throughout the body. It is a member of the interleukin-17 (IL17) family of cytokines, which play a crucial role in the regulation of immune and inflammatory responses. The IL17 receptor is involved in the signaling process that regulates the production and activation of immune cells, making it an attractive drug target for researchers.

The IL17 receptor is a transmembrane protein that is composed of two extracellular domains and an intracellular domain. The extracellular domain consists of a catalytic tyrosine residue, which is responsible for the formation of a covalent complex with a protein called CSL2. The intracellular domain contains a short amino acid tail that is involved in the formation of a complex with the transcription factor, NF-kappa-B.

The IL17 receptor is involved in the regulation of a wide range of physiological processes, including immune responses, inflammation, and tissue repair. It is expressed in a variety of tissues, including the skin, hair, and nails, and is involved in the regulation of cell proliferation, differentiation, and survival.

One of the most significant functions of the IL17 receptor is its role in the regulation of immune responses. The IL17 receptor is involved in the development and activation of T cells, which are a crucial component of the immune system. T cells are responsible for recognizing and responding to foreign antigens, and their activation and proliferation are regulated by the IL17 receptor.

The IL17 receptor is also involved in the regulation of inflammation. When an infection is present, the IL17 receptor is activated and signaling leads to the production and activation of immune cells, including T cells and macrophages. This process is essential for the elimination of pathogens and for the regulation of tissue repair.

In addition to its role in immune and inflammatory responses, the IL17 receptor is also involved in the regulation of cell survival. The IL17 receptor has been shown to play a role in the regulation of cell survival and proliferation, and it is thought to contribute to the development of cancer.

The IL17 receptor is a potential drug target because of its involvement in the regulation of immune and inflammatory responses. Many studies have shown that blocking the IL17 receptor with small molecules can have a variety of therapeutic effects, including the treatment of autoimmune diseases, cancer, and other inflammatory conditions.

In addition to its potential therapeutic applications, the IL17 receptor is also a useful biomarker for the study of inflammation and immune responses. The IL17 receptor is a well-established target for antibodies, and it is possible to use antibodies as a diagnostic tool for the diagnosis of inflammation and immune-related diseases.

Overall, the IL17 receptor is a protein that is involved in a wide range of physiological processes and is a potential drug target for the treatment of a variety of conditions. Further research is needed to fully understand the role of the IL17 receptor in the regulation of immune and inflammatory responses, and to develop effective therapies based on this understanding.

Protein Name: Interleukin 17 Receptor C

Functions: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity)

The "IL17RC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL17RC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A | Immunoglobulin E (IgE) | Immunoglobulin G | Immunoglobulin M | Immunoglobulin-Like Domain Containing Receptor | Immunoproteasome | IMP3 | IMP4 | IMPA1 | IMPA1P1 | IMPA2 | IMPACT | IMPDH1 | IMPDH1P10