IL1R1: A Potential Drug Target for Immune and Inflammatory Diseases

Target Name: IL1R1

NCBI ID: G3554

IL1R1

IL1R1: A Potential Drug Target for Immune and Inflammatory Diseases

IL1R1 (Interleukin 1 Receptor Alpha, Type I) is a protein that is expressed in various tissues throughout the body. It is a type I interleukin receptor, which means it is one of the IL1R family of cytokine receptors. IL1R1 is involved in the regulation of immune and inflammatory responses, and is a potential drug target for several diseases.

IL1R1 is a 24-kDa protein that is expressed in various tissues, including the liver, spleen, and peripheral blood cells. It is primarily localized to the cytoplasm of these cells and is involved in the regulation of cellular processes such as cell adhesion, migration , and survival. IL1R1 is a type I interleukin receptor, which means it consists of an extracellular domain that is responsible for interacting with cytokines and other signaling molecules.

One of the key functions of IL1R1 is its role in the regulation of inflammation. IL1R1 is involved in the production and regulation of pro-inflammatory cytokines, such as interleukin-1 (IL1). IL1 is a potent chemoattractant that can attract immune cells to the site of an infection or injury, and is involved in the recruitment of these cells to the site of inflammation. The activity of IL1R1 is regulated by several intracellular signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway.

IL1R1 is also involved in the regulation of cellular responses to stress and in the regulation of cellular signaling pathways that are involved in cell survival. It is research has shown that IL1R1 is involved in the regulation of cellular responses to stress, including the regulation of cell cycle progression and the production of apoptosis-inducing factors. IL1R1 is also involved in the regulation of cellular signaling pathways that are involved in cell survival, including the production of angiogenic factors and the inhibition of cell apoptosis.

In addition to its role in the regulation of inflammation and cellular responses to stress, IL1R1 is also involved in the regulation of cellular processes that are important for tissue repair and regeneration. It is research has shown that IL1R1 is involved in the regulation of cellular responses to tissue injury and is involved in the production of factors that promote tissue repair and regeneration.

IL1R1 is also a potential drug target for several diseases. For example, it is involved in the regulation of the immune response and has been implicated in the development of autoimmune diseases. Additionally, IL1R1 is involved in the regulation of cellular responses to stress and has been implicated in the development of certain types of cancer.

In conclusion, IL1R1 is a protein that is involved in the regulation of various cellular processes throughout the body. It is a type I interleukin receptor and is primarily localized to the cytoplasm of various cells. IL1R1 is involved in the regulation of inflammation, cellular responses to stress, and cellular processes that are important for tissue repair and regeneration. As a result, IL1R1 is a potential drug target for several diseases and may be a valuable tool for the development of new therapies.

Protein Name: Interleukin 1 Receptor Type 1

Functions: Receptor for IL1A, IL1B and IL1RN (PubMed:2950091). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850)

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