IL-17RA: Key Regulator of Inflammation, Immune Response and Metabolism

IL-17RA: Key Regulator of Inflammation, Immune Response and Metabolism

Interleukin-17 receptor A (ISOform 2), also known as IL-17RA, is a protein that is expressed in a variety of tissues throughout the body. It is a key regulator of inflammation and immune responses, and is involved in the development and regulation of many different diseases, including autoimmune disorders, obesity, and cancer. In recent years, researchers have been increasingly interested in identifying potential drug targets for IL-17RA, in order to develop new treatments for these diseases.

IL-17RA is a member of the IL-17 receptor family, which includes several different isoforms, including ISOform 1, ISOform 2, and ISOform 3. These isoforms are involved in the regulation of various cellular processes, including inflammation, immune responses, and metabolism. IL-17RA is the most well-studied of the IL-17 receptor family isoforms, and is involved in the regulation of many different cellular processes, including inflammation, immune responses, and metabolism.

One of the key functions of IL-17RA is its role in the regulation of inflammation. IL-17RA is involved in the production and regulation of pro-inflammatory cytokines, which are important drivers of inflammation. It is also involved in the regulation of anti -inflammatory cytokines, which help to counteract the pro-inflammatory effects of cytokines. These activities make IL-17RA an important regulator of inflammation, and are the subject of ongoing research as potential drug targets.

In addition to its role in inflammation, IL-17RA is also involved in the regulation of immune responses. It is involved in the regulation of T cell development and function, and is involved in the regulation of the immune response to infection. These activities make IL-17RA is an important regulator of immune responses, and is the subject of ongoing research as potential drug targets.

IL-17RA is also involved in the regulation of metabolism, and is involved in the regulation of energy metabolism and the production of glucose. These activities make IL-17RA an important regulator of metabolism, and are the subject of ongoing research as potential drug targets.

In conclusion, IL-17RA is a protein that is involved in the regulation of inflammation, immune responses, and metabolism. As a result, it is an attractive target for drug development, and is the subject of ongoing research as a potential drug. Furthermore , the identification and characterization of new isoforms of IL-17RA, such as ISOform 4, may provide new insights into the regulation of this protein and its potential as a drug target.

Protein Name: Interleukin 17 Receptor A

Functions: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)

The "IL17RA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL17RA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A | Immunoglobulin E (IgE) | Immunoglobulin G | Immunoglobulin M | Immunoglobulin-Like Domain Containing Receptor | Immunoproteasome | IMP3 | IMP4 | IMPA1 | IMPA1P1 | IMPA2 | IMPACT