Trav27: A Protein Involved in Cell Signaling, Adhesion and Survival

Target Name: TRAV27

NCBI ID: G28655

TRAV27

Other Name(s): TCRAV27S1 | T cell receptor alpha variable 27 | TCRAV10S1

Trav27: A Protein Involved in Cell Signaling, Adhesion and Survival

Trav27 (TCA27) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is a member of the transforming growth factor beta (TGF-β) family, which is involved in cell growth, differentiation, and survival. Trav27 has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, Trav27 has become a focus of interest for researchers and pharmaceutical companies.

One of the key features of Trav27 is its role in cell signaling. It is a potent negative regulator of the TGF-β signaling pathway, which is involved in promoting cell growth, differentiation, and survival. The TGF-β pathway is a critical factor in the development and maintenance of tissues, and it is often involved in the development of diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. Trav27 has been shown to play a role in regulating TGF-β signaling by inhibiting the activity of the transcription factor SMAD, which is a key component of the TGF-β pathway.

Another important function of Trav27 is its role in cell adhesion. Trav27 is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and prevent fluid from extravasation. Trav27 has also been shown to play a role in the regulation of cell-cell adhesion by inhibiting the activity of the protein Desmoplakin, which is involved in the formation of tight junctions.

In addition to its role in cell signaling and adhesion, Trav27 is also involved in the regulation of cell survival. Studies have shown that Trav27 can induce the expression of genes that are involved in cell survival, such as the gene p53, which is a well -known tumor suppressor gene. This suggests that Trav27 may have a role in the development and progression of certain diseases.

Trav27 has also been shown to play a role in the regulation of inflammation. Studies have shown that Trav27 can induce the production of pro-inflammatory cytokines, such as TNF-伪 and IL-1尾, which can contribute to the development of inflammatory diseases. This suggests that Trav27 may have a role in the development of certain inflammatory diseases.

Despite its potential role in several diseases, Trav27 is still not well understood. There are many questions that need to be answered about the mechanisms of Trav27's function in these diseases, including its precise mechanism of action and its role in the development and progression of these diseases. In addition, there is a need for more research on the potential therapeutic benefits of Trav27. As a potential drug target, Trav27 has the potential to be used in the development of new treatments for a variety of diseases.

Protein Name: T Cell Receptor Alpha Variable 27

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV27 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV27 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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