Target Name: IL13
NCBI ID: G3596
Review Report on IL13 Target / Biomarker Content of Review Report on IL13 Target / Biomarker
IL13
Other Name(s): interleukin 13 | IL-13 | IL13_HUMAN | Interleukin 13, transcript variant 1 | P600 | IL13 variant 1 | Interleukin-13 | Interleukin-13 (isoform 1)

IL-13: A Pro-Inflammatory Cytokine with Multiple Functions

Interleukin 13 (IL-13) is a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. It is a pro-inflammatory cytokine that is produced by various cell types in the body, including macrophages, dendritic cells, and epithelial cells. IL-13 is known for its ability to recruit and activate immune cells, such as T cells and macrophages, which are essential for the immune response.

One of the key functions of IL-13 is its ability to stimulate the production of new antibodies. When an IL-13 receptor is activated, it can induce the B cell to undergo clonal expansion and differentiate into antibody-secreting plasma cells. This is important for the development and maintenance of an effective immune response to infections and other threats.

Another important function of IL-13 is its role in the regulation of inflammation. When an IL-13 receptor is activated, it can stimulate the production of pro-inflammatory cytokines, such as IL-1尾 and IL-6. These cytokines are important for the recruitment and activation of immune cells, such as neutrophils, which are critical for the elimination of pathogens and damaged tissue.

IL-13 is also involved in the regulation of cellular processes that are important for tissue repair and regeneration. When an IL-13 receptor is activated, it can induce the production of regulatory T cells, which are responsible for maintaining the stem cell pool and promoting the differentiation of progeny into tissues. This is important for the development and maintenance of tissues and organs, and for the regulation of wound healing and tissue regeneration.

Despite its many important functions, IL-13 is also known to be a drug target. Several studies have identified potential inhibitors of IL-13, which could be used to treat a variety of conditions, including autoimmune diseases, cancer, and chronic obstructive pulmonary disease (COPD). These inhibitors have been shown to have a variety of therapeutic effects, including the inhibition of immune cell function and the regulation of inflammatory responses.

In addition to its potential therapeutic uses, IL-13 is also widely studied as a biomarker for a variety of diseases. The production of IL-13 has been shown to be involved in the development of a number of diseases, including cancer, autoimmune diseases, and bacterial infections. For example, high levels of IL-13 have been observed in the blood of individuals with rheumatoid arthritis, a common autoimmune disease. Similarly, the production of IL-13 has been associated with the development of a variety of bacterial infections, including sepsis and pneumonia.

Overall, IL-13 is a complex cytokine that plays an important role in the regulation of immune and inflammatory responses. Its potential therapeutic uses and its involvement as a biomarker for a variety of diseases make it an attractive target for further research and development. As research continues to advance, it is likely that new insights into the biology and pharmacology of IL-13 will emerge, further expanding its potential uses and applications.

Protein Name: Interleukin 13

Functions: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864)

The "IL13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A