IL-17C and IL-17R: Key Players in Immunity and Disease (G27189)
IL-17C and IL-17R: Key Players in Immunity and Disease
IL-17C, also known as interleukin-17 cell surface protein (IL-17SPP), is a protein that is expressed in various tissues throughout the body, including the immune system, skin, and nervous system. It is a member of the IL-17 family of cytokines, which play a crucial role in the regulation of immune and inflammatory responses.
One of the key functions of IL-17C is its ability to stimulate the production of other cytokines and chemokines, which are proteins that are involved in the immune response and inflammation. This is accomplished through the interaction of IL-17C with its receptor, which is a protein called IL-17R.
IL-17R is a protein that is expressed in various tissues throughout the body, including the immune system, and is involved in the regulation of the immune response and inflammation. It is a member of the IL-1 receptor family, which includes proteins that are involved in the signaling of cytokines and chemokines.
IL-17C and IL-17R have been shown to play a role in the development and progression of a number of diseases, including cancer, autoimmune diseases, and chronic obstructive pulmonary disease (COPD). For example, studies have shown that high levels of IL-17C and IL-17R are associated with an increased risk of developing skin cancer, and that these proteins may also play a role in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
In addition to their potential role in disease, IL-17C and IL-17R are also of interest as potential drug targets. For example, studies have shown that inhibiting the activity of IL-17C or IL-17R has the potential to treat a number of diseases, including cancer, autoimmune diseases, and COPD. Additionally, the development of drugs that target IL-17C and IL-17R may also have the potential to revolutionize the field of regenerative medicine, as these proteins have been shown to play a role in the regulation of stem cell proliferation and differentiation.
Overall, IL-17C and IL-17R are important proteins that have the potential to revolutionize our understanding of the immune system and the regulation of inflammation. Further research is needed to fully understand the role of these proteins in disease and to develop effective treatments.
Protein Name: Interleukin 17C
Functions: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases
The "IL17C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL17C comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A | Immunoglobulin E (IgE) | Immunoglobulin G | Immunoglobulin M | Immunoglobulin-Like Domain Containing Receptor | Immunoproteasome | IMP3 | IMP4 | IMPA1
