Understanding The Role of NDUFB5 in Neurological Diseases (G4711)

Target Name: NDUFB5

NCBI ID: G4711

NDUFB5

Understanding The Role of NDUFB5 in Neurological Diseases

Native Domain Unified Functional Brain-specific gene domain (NDUFB5) is a gene located on human chromosome 1p36.1. It is a member of the brain sulfate (SO42-) synthetase family and participates in a variety of biochemical reactions within cells. NDUFB5 is expressed in spinal cord and brain tissue and plays an important role in a variety of neurological diseases.

In recent years, researchers have found that NDUFB5 is elevated in certain neurological diseases, such as Parkinson's disease, Alzheimer's disease, autism, etc. In addition, the expression level of NDUFB5 is also related to many neurological symptoms and neuroimaging parameters, such as cognitive function, neurodegeneration, neuroinflammation, etc. Therefore, NDUFB5 is considered a potential drug target and biomarker.

The function and mechanism of action of NDUFB5 are not fully understood, but it is known to affect nervous system function in a variety of ways. First, NDUFB5 is a member of the sulfate synthase family, whose genes are specifically expressed in the nervous system. The sulfate synthase family includes a variety of transcription factors, such as SOX10, HSF1, etc., which play a role in the development, structure and function of the nervous system. As a member of this family, NDUFB5 may maintain nervous system development and function by regulating sulfate synthesis and degradation.

Secondly, NDUFB5 participates in a variety of biochemical reactions in the nervous system, including energy metabolism, cell proliferation, apoptosis, etc. For example, NDUFB5 plays a role in the metabolic pathways of neurons and may affect neuronal survival and apoptosis. In addition, NDUFB5 is also involved in the proliferation and differentiation of nerve cells, which may be relevant to the treatment of neuronal diseases.

Furthermore, NDUFB5 is associated with a variety of diseases and symptoms in the nervous system. For example, NDUFB5 is elevated in patients with Parkinson's disease and is positively correlated with clinical manifestations and neuroimaging parameters of Parkinson's disease. In patients with Alzheimer's disease, elevated NDUFB5 is associated with increased risk of neuronal loss and overall death. In addition, NDUFB5 is also related to autism and autistic tendencies and may play a role in the treatment of autism.

Therefore, NDUFB5 has broad application prospects as a drug target and biomarker in neurological diseases. Future research can focus on the following aspects: first, in-depth study of the function and mechanism of action of NDUFB5 to better understand its role in neurological diseases. Secondly, develop NDUFB5 as a drug target and biomarker to treat neurological diseases. Finally, study the relationship between NDUFB5 and neurological diseases to develop more precise diagnostic methods and treatment options.

Protein Name: NADH:ubiquinone Oxidoreductase Subunit B5

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

The "NDUFB5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NDUFB5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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