Discovering RNASE4: A RNA Degradase with Potential as A Drug Target
Discovering RNASE4: A RNA Degradase with Potential as A Drug Target
Ribonuclease (RNase) family member 4 (RNASE4) is a water-soluble enzyme that plays a crucial role in the regulation of RNA homeostasis. It is a member of the RNase A family, which includes RNase A, RNase B, and RNase C. RNASE4 is responsible for the degradation of single-stranded RNA (ssRNA), which is a common form of RNA found in various biological systems.
The discovery of RNASE4 and its functions have important implications for the study of RNA biology and the development of new therapeutics. The RNA universe is vast and diverse, and RNA molecules play a critical role in the regulation of gene expression, DNA replication, and cellular processes. RNASE4's role in the degradation of ssRNA suggests that it may have a potential as a drug target or biomarker.
The development of RNA-based therapeutics is an active area of research, with a focus on small molecules and natural compounds that can interact with specific RNA molecules to modulate their activity. RNASE4 is an attractive target due to its unique structure and the diverse range of functions it plays in various cellular processes.
RNASE4 is a member of the RNA-protein superfamily, which includes enzymes that carry out various functions in the regulation of RNA molecules, such as splicing, processing, and degradation. The RNA-protein superfamily is a large and diverse family that includes over 1,600 known enzymes, many of which are involved in the regulation of gene expression and cellular processes.
The RNase A family is a subgroup of the RNA-protein superfamily that is characterized by the presence of a specific active site in the protein that allows for the recognition and cleavage of RNA. The active site is a unique region of the protein that is optimized for the recognition of specific RNA targets, and it is the site of the enzyme's catalytic activity.
RNASE4 is a member of the RNase A family and has a characteristic active site that allows it to recognize and cleave specific RNA targets. The active site is composed of a unique nucleotide sequence that includes a 5'-end and a 3'-end region that are involved in the recognition of the RNA target. The 5'-end region includes a specific base that is involved in the recognition of the RNA target, while the 3'-end region includes a specific base that is involved in the cleavage of the RNA.
The cleavage mechanism of RNase4 is similar to that of other members of the RNase A family. It uses a specific 2-dimensional cleavage mechanism that involves the formation of a double-stranded RNA break. The cleavage mechanism is optimally suited for the recognition of specific RNA targets, and it allows RNase4 to cleave RNA with high accuracy and efficiency.
The functions of RNase4 are diverse and include the regulation of gene expression, DNA replication, and cellular processes. It is involved in the degradation of various types of RNA, including mRNA, tRNA, and rRNA. The degradation of RNA by RNase4 is essential for the regulation of gene expression, as it helps to remove non-coding RNA that is not required for protein production.
In addition to its role in gene expression regulation, RNase4 is also involved in the regulation of DNA replication. It has been shown to be involved in the degradation of single-stranded DNA that is present in the reaction mixture during the DNA replication process. This degradation of DNA by RNase4 helps to ensure the accuracy and efficiency of DNA replication.
The role of RNase4 in cellular processes is also significant. It is involved in the regulation of various cellular processes, including cell signaling, cell division, and cellular growth. It is also involved in the regulation of cellular interactions, such as cell-cell adhesion and cell-extracellular matrix interactions.
The potential of RNase4 as a drug target is high due to its unique structure and the diverse range of functions it plays in various cellular processes. The development of RNA-based therapeutics is an active area of research, and RNase4 is an
Protein Name: Ribonuclease A Family Member 4
Functions: This RNase has marked specificity towards the 3' side of uridine nucleotides
The "RNASE4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASE4 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
RNASE6 | RNASE7 | RNASE8 | RNASE9 | RNASEH1 | RNASEH1-DT | RNASEH2A | RNASEH2B | RNASEH2B-AS1 | RNASEH2C | RNASEH2CP1 | RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38
