Target Name: RNASE7
NCBI ID: G84659
Review Report on RNASE7 Target / Biomarker Content of Review Report on RNASE7 Target / Biomarker
RNASE7
Other Name(s): MGC133220 | ribonuclease A family member 7 | Ribonuclease RNase A family 7 | RNase 7 | RNAse 7 | ribonuclease, RNase A family, 7 | Skin-derived antimicrobial protein 2 | skin-derived antimicrobial protein 2 | RAE1 | Ribonuclease 7 | RNAS7_HUMAN | SAP-2 | Ribonuclease 7 precursor | Ribonuclease A family member 7

RNA-Nuclease 7: A Promising Drug Target Forvarious Diseases

RNA-associated Nucleases (RANs) are a family of enzymes that play a crucial role in the regulation of gene expression and post-transcriptional modification of RNA. One of the well-studied RANs is RNA-Nuclease (RNA-N)7 (MGC133220 ), which is a key enzyme in the RNA-Nuclease family. RNA-Nuclease 7 is a 21 kDa protein that is expressed in a variety of cell types and is involved in the processing of RNA for degradation and removal of post-transcriptional modifications.

RNA-Nuclease 7 is a key enzyme in the RNA-Nuclease family, and its function is to remove 5鈥?-end RNA modifications from pre-mRNA. These modifications include 5鈥?-end fidelity modifications, such as upstream and downstream phosphate , guanylation, methylation, etc., which can affect the structure, stability and translation efficiency of RNA, thereby affecting the biological functions of cells. RNA-Nuclease 7 can remove phosphorylation modifications on RNA by catalyzing the 5'-end phosphorylation of RNA, including phosphodiesterase activity, phosphoenolate malonate synthase activity, and the binding of RNA-binding proteins to RNA. Ability.

Inhibition of RNA-Nuclease 7 leads to the accumulation of RNA modifications, leading to disorders of cell biological functions. For example, deletion of RNA-Nuclease 7 leads to the accumulation of RNA modifications in mouse embryonic stem cells, leading to failure of embryonic stem cell differentiation and ultimately the formation of embryos with developmental abnormalities. In tumors, inhibition of RNA-Nuclease 7 is also considered to be one of the important mechanisms in tumor occurrence and development. Inhibition of RNA-Nuclease 7 can lead to increased tumor cell growth and metastasis, adversely affecting patient health.

In addition to its role in tumors, RNA-Nuclease 7 also plays an important role in embryonic development. RNA-Nuclease 7 plays an important role in embryonic stem cell differentiation, organ formation and cell proliferation. The loss of RNA-Nuclease 7 will lead to abnormal differentiation of embryonic stem cells, leading to abnormal development of tissues and organs, and ultimately the death of the embryo. Therefore, the role of RNA-Nuclease 7 in embryonic development has also attracted widespread attention.

In recent years, researchers have conducted in-depth studies on the function of RNA-Nuclease 7 and discovered the application prospects of RNA-Nuclease 7 in drug discovery and treatment. RNA-Nuclease 7 can be used as a potential drug target to treat a variety of diseases, including cancer, neurodegenerative diseases, and immune-related diseases.

First, RNA-Nuclease 7 is a good drug target because it is expressed in a variety of tumors and its inhibition has significant efficacy in tumor treatment. Inhibition of RNA-Nuclease 7 can lead to apoptosis of tumor cells, thus having a positive impact on tumor treatment.

Secondly, RNA-Nuclease 7 also has potential application value in neurodegenerative diseases. RNA-Nuclease 7 plays an important role in neurodegenerative diseases, and its inhibition can slow down the progression of neurodegenerative diseases, thereby having a positive impact on the treatment of the disease.

In addition, RNA-Nuclease 7 is also closely related to the immune system. RNA-Nuclease 7 is expressed in immune cells, and its inhibition can inhibit the response of immune cells, thus playing an important role in the regulation of the immune system.

In summary, RNA-Nuclease 7 is a potential drug target that can be used to treat a variety of diseases. Future research will focus on the application value of RNA-Nuclease 7 in drug discovery and treatment, as well as its important role in the biomedical field. With the deepening of research, RNA-Nuclease 7 will play a more important role in drug discovery and treatment.

Protein Name: Ribonuclease A Family Member 7

Functions: Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966)

The "RNASE7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASE7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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