GPATCH3: A Potential Drug Target and Biomarker (G63906)
GPATCH3: A Potential Drug Target and Biomarker
G-patch domain containing 3 (GPATCH3) is a gene located on chromosome 16q24. It is a small non-coding RNA molecule that has been shown to play a role in various cellular processes, including cell adhesion, migration, and invasion. patch domain containing 3 has also been implicated in the development and progression of various diseases, including cancer. As a result, G-patch domain containing 3 has emerged as a promising drug target and biomarker.
The G-patch domain containing 3 genes has four exons, which encode a 23 amino acid protein. This protein is composed of a N-terminal transmembrane domain, a catalytic domain, and a C-terminal cytoplasmic domain. The N-terminal transmembrane domain is responsible for the protein's ability to interact with various cell surface molecules, while the catalytic domain is responsible for the protein's catalytic activity. The C-terminal cytoplasmic domain is responsible for the protein's ability to interact with intracellular signaling molecules.
G-patch domain containing 3 has been shown to play a role in cell adhesion and migration. G-patch domain containing 3 has been shown to interact with the protein Integrin, which is a transmembrane protein that is involved in cell adhesion. and migration. The interaction between G-patch domain containing 3 and Integrin has been shown to promote the growth and migration of various cell types. This suggests that G-patch domain containing 3 may be a drug target that can be targeted with small molecules or antibodies to inhibit its function.
G-patch domain containing 3 has also been shown to be involved in the development and progression of various diseases, including cancer. Many studies have shown that G-patch domain containing 3 is overexpressed or hypermethylated in various types of cancer, including breast, ovarian , and colorectal cancer. The overexpression or hypermethylation of G-patch domain containing 3 has been shown to promote the growth and survival of cancer cells, suggesting that it may be a useful biomarker or drug target in cancer treatment.
In addition to its role in cell adhesion and migration, G-patch domain containing 3 has also been shown to play a role in the regulation of cell cycle progression. The G-patch domain containing 3 protein has been shown to interact with the protein p21 (TOR), which is a transcription factor that is involved in the regulation of cell cycle progression. The interaction between G-patch domain containing 3 and p21 has been shown to promote the growth and proliferation of various cell types, suggesting that G-patch domain containing 3 may be a drug target that can be targeted with small molecules or antibodies to inhibit its function.
The G-patch domain containing 3 has also been shown to play a role in the regulation of cellular signaling pathways. The G-patch domain containing 3 protein has been shown to interact with the protein FAK (focal adhesion kinase), which is a protein that is involved in the regulation of cell signaling pathways. The interaction between G-patch domain containing 3 and FAK has been shown to promote the formation of focal adhesion clusters, which are thought to play a role in the regulation of cellular signaling pathways.
In conclusion, G-patch domain containing 3 is a gene that has been shown to play a role in various cellular processes, including cell adhesion, migration, and invasion. Its interaction with Integrin, p21, and FAK suggests that it may be a drug target or biomarker for various diseases, including cancer. Further research is needed to fully understand the function of G-patch domain containing 3 and its potential as a drug target or biomarker.
Protein Name: G-patch Domain Containing 3
Functions: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768)
The "GPATCH3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPATCH3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55
