GPC1: Role in Cell Adhesion, Signaling Pathways and Tissue Regeneration
GPC1: Role in Cell Adhesion, Signaling Pathways and Tissue Regeneration
GPC1, also known as secreted glypican-1 (SGIP-1), is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and blood cells. It is a member of the glypican family, which is a group of non-coding RNA-binding proteins that play a role in cell signaling and tissue repair.
GPC1 is characterized by its extracellular domain, which consists of a long amino acid sequence that is responsible for its ability to interact with various cytoplasmic proteins. This interaction with other proteins allows GPC1 to participate in a variety of cellular processes, including cell adhesion, migration, and signaling pathways.
One of the most significant functions of GPC1 is its role in the regulation of cell adhesion. GPC1 is known to be involved in the formation of tight junctions, which are specialized junctions that mediate the transfer of electrical signals between cells. These connections are critical for maintaining the integrity of the blood-brain barrier, which is responsible for maintaining the barrier between the brain and the bloodstream.
In addition to its role in cell adhesion, GPC1 is also involved in the regulation of cell signaling pathways. For example, GPC1 has been shown to be involved in the regulation of theNotch signaling pathway, which is a critical pathway that regulates cell proliferation and survival.
GPC1 is also expressed in various tissues and has been shown to play a role in the regulation of inflammation. For example, GPC1 has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha and IL-8.
GPC1 is also involved in the regulation of cell cycle progression. It has been shown to play a role in the regulation of the G1/S transition, which is a critical step in the cell cycle that is responsible for the maintenance of cellular homeostasis.
GPC1 is also involved in the regulation of cellular signaling pathways that are critical for tissue repair and regeneration. For example, GPC1 has been shown to be involved in the regulation of the Wnt signaling pathway, which is responsible for the regulation of cell growth and differentiation during development and tissue repair.
GPC1 is also involved in the regulation of cell signaling pathways that are critical for the development and maintenance of tissues. For example, GPC1 has been shown to be involved in the regulation of the FGF signaling pathway, which is responsible for the regulation of cell growth and differentiation during development.
In conclusion, GPC1 is a protein that is involved in a variety of cellular processes that are critical for the development and maintenance of tissues. Its role in cell adhesion, signaling pathways, inflammation, and cellular cycle progression are just a few examples of its functions. As a result, GPC1 is an attractive drug target and may be a useful biomarker for the diagnosis and treatment of various diseases.
Protein Name: Glypican 1
Functions: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling
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More Common Targets
GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68
