GSTO1: Monomethylarsonic Acid Reductase Gene Encodes A Protein in Redox Homeostasis and Cellular Metabolism

Target Name: GSTO1

NCBI ID: G9446

GSTO1

GSTO1: Monomethylarsonic Acid Reductase Gene Encodes A Protein in Redox Homeostasis and Cellular Metabolism

GSTO1 (Monomethylarsonic Acid Reductase) is a gene that encodes a protein known as monomethylarsonic acid reductase. This protein plays a crucial role in the process of redox homeostasis, which is the ability of cells to maintain a stable balance of electrical potential across their membranes.

GSTO1 is expressed in almost all eukaryotic cells, including mammals, birds, fish and insects. It plays important biological functions in cells and participates in various metabolic pathways.

Functions of GSTO1

The main function of GSTO1 is to catalyze an important metabolic reaction, namely the reduction of monomethylarsonic acid (MMA). MMA is an organic acid found in many organisms and is highly toxic. GSTO1 protects cells from MMA damage by reducing MMA and participates in the normal metabolic process of cells.

The reduction effect of GSTO1 is achieved by reducing MMA to MMA-glutathione, a very stable molecule. During this process, the active center of GSTO1 is oxidized and releases electrons, which are used to reduce MMA to MMA-glutathione.

Regulation of GSTO1

The activity of GSTO1 is regulated by many factors, including substrate concentration, temperature and pH value. In cells, the activity of GSTO1 is usually regulated by a series of signaling molecules, including insulin, Wnt, FGF and Hedgehog.

GSTO1 interaction

GSTO1 plays important interactions within cells. GSTO1 can interact with other proteins, including some transcription factors such as RNA polymerase II and activator protein 1 (AP-1). These interactions can affect the activity of GSTO1 and participate in cellular metabolic pathways.

Clinical applications of GSTO1

GSTO1 has received attention in many biomedical studies and has been considered as a potential drug target. The activity of GSTO1 can be used to treat many diseases, including neurological diseases, immune system diseases and tumors.

For example, the activity of GSTO1 has been used to treat neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In addition, GSTO1 is also used as a tumor biomarker, which can be used to predict tumor aggressiveness and treatment response.

Biological significance of GSTO1

GSTO1 is an important gene that plays important biological functions in cells. The activity of GSTO1 can be used to treat many diseases and is considered a potential drug target. In the future, research will continue to deeply explore the biological functions of GSTO1 and explore its potential in medicine.

Protein Name: Glutathione S-transferase Omega 1

Functions: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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