IL12R?2: A Protein Regulating Immune and Pain Signaling (G3595)

IL12R?2: A Protein Regulating Immune and Pain Signaling

Interleukin 12 (IL12) is a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. The IL12 receptor subunit beta 2 (IL12R尾2) is a protein that is expressed in various tissues and cells, including immune cells, neurons, and tissues. It is known for its role in the regulation of inflammation, immune cell function, and cellular communication.

IL12R尾2 is a six-transmembrane protein that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of IL12R尾2 consists of a catalytic domain, a leucine-rich repeat (LRR), and a hinge region. The LRR is a unique feature that is found in proteins that are involved in cell signaling, including IL12R尾2. The transmembrane domain of IL12R尾2 is composed of a single membrane, which is involved in the regulation of the cellular signaling pathway. The intracellular domain of IL12R尾2 is composed of a single protein that is involved in the regulation of cellular signaling pathways.

The role of IL12R尾2 in the regulation of immune responses is well established. IL12R尾2 is involved in the regulation of T cell development and function, as well as the regulation of immune cell cytokine production. It is also involved in the regulation of the production of regulatory T cells, which play a critical role in the regulation of immune responses.

IL12R尾2 is also involved in the regulation of pain signaling. It is known to be involved in the regulation of nociceitin-induced pain hypersensitivity in animals.

Despite the fact that IL12R尾2 is involved in a wide range of cellular processes, it is still an attractive drug target. The ability of IL12R尾2 to regulate immune and inflammatory responses makes it an attractive target for small molecule inhibitors. Additionally, the role of IL12R尾2 in the regulation of pain signaling makes it an attractive target for opioids.

In conclusion, IL12R尾2 is a protein that is involved in the regulation of a wide range of cellular processes. Its role in the regulation of immune and inflammatory responses makes it an attractive drug target, and its role in the regulation of pain signaling makes it an attractive target for small molecule inhibitors and opioids. Further research is needed to fully understand the role of IL12R尾2 in cellular signaling and its potential as a drug target.

Protein Name: Interleukin 12 Receptor Subunit Beta 2

Functions: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production

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IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1