IL-12R?1: Key Regulator of Immune and Inflammatory Processes (G3594)
IL-12R?1: Key Regulator of Immune and Inflammatory Processes
IL-12R尾1 (Interleukin-12 receptor subunit beta-1) is a protein that is expressed in various tissues and cells throughout the body. It is a key receptor for interleukin-12 (IL-12), a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. The IL-12R尾1 receptor is involved in the signaling cascade that regulates the production and activity of various immune cells, including T cells, B cells, and natural killer cells.
IL-12R尾1 is a cytoplasmic protein that is expressed in most tissues and cells of the body, including the skin, hair, nails, liver, spleen, thymus, bone marrow, and various other organs. It is a member of the IL-12 receptor subfamily, which includes several other cytokine receptors, including IL-12R伪, IL-12R尾2, and IL-12R纬. The IL-12 receptor subfamily is involved in the regulation of cellular immune responses, including the regulation of T cell development and function, as well as the regulation of inflammation.
IL-12R尾1 is involved in the signaling cascade that regulates the production and activity of various immune cells. When IL-12 is administered to immune cells, it can activate the IL-12R尾1 receptor, which then activates downstream signaling pathways that regulate the production and activity of those immune cells. For example, when IL-12 is administered to T cells, it can activate the IL-12R尾1 receptor, which then activates downstream signaling pathways that regulate the production and activity of T cells, including the development and activation of memory T cells.
IL-12R尾1 is also involved in the regulation of cellular processes that are important for tissue repair and regeneration. When immune cells are activated and divide, IL-12 can activate the IL-12R尾1 receptor, which then activates downstream signaling pathways that regulate the production and activity of those immune cells. This helps to ensure that immune cells are able to differentiate into regulatory T cells, which help to maintain and regulate the immune system.
In addition to its role in the regulation of immune cells, IL-12R尾1 is also involved in the regulation of cellular processes that are important for tissue growth and development. When IL-12 is administered to fibroblasts, which are cells that are involved in the production of extracellular matrix (ECM) components, it can activate the IL-12R尾1 receptor, which then activates downstream signaling pathways that regulate the production and activity of those fibroblasts. This helps to ensure that fibroblasts are able to produce ECM components at a rate that is necessary for tissue growth and development.
IL-12R尾1 is also involved in the regulation of cellular processes that are important for cell survival and apoptosis. When IL-12 is administered to immune cells, it can activate the IL-12R尾1 receptor, which then activates downstream signaling pathways that regulate the production and activity of those immune cells. This helps to ensure that immune cells are able to survive and continue to function in the face of various challenges, including the presence of cancer cells.
In conclusion, IL-12R尾1 is a protein that is involved in the regulation of various cellular processes that are important for immune and inflammatory responses, tissue repair and regeneration, and cell survival and apoptosis. As a result, it is a potential drug target and biomarker for a variety of diseases, including cancer, autoimmune diseases, and inflammatory disorders. Further research is needed to fully understand the role of IL-12R尾1 in these processes, as well as to develop effective therapies that can target this protein.
Protein Name: Interleukin 12 Receptor Subunit Beta 1
Functions: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade
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More Common Targets
IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT
