IL-11: A Promising Drug Target for Future Treatment (G3589)
IL-11: A Promising Drug Target for Future Treatment
IL-11 (Interleukin 11, transcript variant 1) is a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. It is a cytokine that is produced by various tissues in the body, including the immune system, and it has been shown to play a key role in the development and progression of a number of diseases, including cancer, obesity, and diabetes.
IL-11 has been identified as a potential drug target due to its ability to regulate the immune response and its role in the development of certain diseases. It is produced by various tissues in the body, including the immune system, and it has been shown to play a key role in the regulation of the immune response.
One of the key functions of IL-11 is its ability to stimulate the production of immune cells, such as T cells and B cells. It does this by interacting with the cytoplasm of these cells, which allows it to communicate with them and stimulate them to produce antibodies and other immune molecules. This is important for maintaining the immune system and protecting the body against infection.
In addition to its role in the immune system, IL-11 has also been shown to play a key role in the regulation of inflammation. It is produced by certain types of immune cells, including macrophages, and it has been shown to help regulate the production of pro-inflammatory molecules. This is important for maintaining a balance between inflammation and inflammation suppression.
IL-11 has also been shown to play a key role in the regulation of cellular processes that are important for the development and progression of certain diseases, such as cancer and obesity. It is produced by various types of cancer cells and has been shown to promote the growth and survival of these cells. In addition, it has also been shown to contribute to the development and progression of obesity by promoting the production of fat cells.
Despite its potential as a drug target, IL-11 is still a relatively little-known cytokine. There are currently no FDA-approved drugs that are specifically designed to target IL-11. However, research is ongoing to determine the potential benefits and risks of using IL-11 as a drug.
In conclusion, IL-11 is a cytokine that plays a crucial role in the regulation of the immune and inflammatory responses in the body. It is produced by various tissues in the body and has been shown to play a key role in the development and progression of a number of diseases, including cancer and obesity. As a result, IL-11 is a promising target for future drug development. Further research is needed to fully understand the potential benefits and risks of using IL-11 as a drug.
Protein Name: Interleukin 11
Functions: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168)
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• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
IL11RA | IL12A | IL12A-AS1 | IL12B | IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2)
