Target Name: IL10
NCBI ID: G3586
Review Report on IL10 Target / Biomarker Content of Review Report on IL10 Target / Biomarker
IL10
Other Name(s): Interleukin-10 (isoform 1) | IL-10 | T-cell growth inhibitory factor | IL10 variant 1 | Cytokine synthesis inhibitory factor | Interleukin-10 (IL-10) | IL10_HUMAN | CSIF | cytokine synthesis inhibitory factor | Interleukin 10, transcript variant 1 | GVHDS | interleukin 10 | Interleukin-10 | IL10A | TGIF

Understanding IL-10: Potential Drug Target Or Biomarker

IL-10 (Interleukin-10) is a cytokine that plays a crucial role in the immune system and has been linked to a number of diseases, including cancer, autoimmune disorders, and chronic obstructive pulmonary disease (COPD). Despite its importance, little is known about IL-10 as a drug target or biomarker. In this article, we will explore the biology and clinical potential of IL-10, as well as its potential as a drug target.

The biology of IL-10

IL-10 is a cytokine that is produced by a variety of tissues in the body, including the immune system, tissues of the skin, and the nervous system. It is a type of cytokine that is derived from the interleukin-1 family of proteins , which are a group of cytokines that play a critical role in the immune response.

IL-10 is involved in a wide range of physiological processes in the body, including immune surveillance, inflammation, and tissue repair. It is produced in response to the presence of pathogens or other stressors, and it has been shown to have a number of important functions in these processes.

One of the key functions of IL-10 is its role in immune surveillance. IL-10 is able to communicate with T cells, which are a critical part of the immune system, and help to coordinate the immune response. It is also involved in the regulation of inflammation, and has been shown to have anti-inflammatory effects.

In addition to its role in the immune system, IL-10 is involved in a number of other physiological processes in the body. It is involved in tissue repair, and has been shown to have a number of roles in this process, including the regulation of cell proliferation and the production of new tissue growth factors. IL-10 is also involved in the regulation of pain, and has been shown to have anti-inflammatory effects in this process.

The clinical potential of IL-10

While IL-10 is involved in a wide range of important physiological processes in the body, much is still not known about its role in human disease. As a result, the potential clinical applications of IL-10 are limited. However, there is some interest in using IL-10 as a drug target or biomarker, in order to better understand its role in human disease.

One potential application of IL-10 as a drug target is its ability to modulate the immune response. IL-10 has been shown to have a number of immune-modulatory effects, including the regulation of T cell activity and the production of antibodies. As As a result, IL-10 has been shown to have potential as a vaccine adjuvant, or as a treatment for a variety of autoimmune disorders.

Another potential application of IL-10 is its ability to modulate inflammation. IL-10 has been shown to have a number of anti-inflammatory effects, including the regulation of cytokine production and the modulation of pain perception. As a result, IL-10 has been shown to have potential as an anti-inflammatory drug, or as a treatment for a variety of inflammatory disorders.

While the potential clinical applications of IL-10 are still being explored, it is clear that this cytokine has a great deal of potential as a drug target or biomarker. Further research is needed to fully understand the role of IL-10 in human disease, and to explore its potential as a therapeutic agent.

Conclusion

IL-10 is a cytokine that is involved in a wide range of important physiological processes in the body. While its potential clinical applications are still being explored, it is clear that IL-10 has a great deal of potential as a drug target or biomarker . Further research is needed to fully understand the role of IL-10 in human disease and to explore its potential as a therapeutic agent.

Protein Name: Interleukin 10

Functions: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)

The "IL10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IL10RA | IL10RB | IL10RB-DT | IL11 | IL11RA | IL12A | IL12A-AS1 | IL12B | IL12RB1 | IL12RB2 | IL13 | IL13RA1 | IL13RA2 | IL15 | IL15RA | IL16 | IL17A | IL17B | IL17C | IL17D | IL17F | IL17RA | IL17RB | IL17RC | IL17RD | IL17RE | IL17REL | IL18 | IL18BP | IL18R1 | IL18RAP | IL19 | IL1A | IL1B | IL1F10 | IL1R1 | IL1R2 | IL1RAP | IL1RAPL1 | IL1RAPL2 | IL1RL1 | IL1RL2 | IL1RN | IL2 | IL20 | IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK