NDUFAF3: A Potential Drug Target and Biomarker (G25915)

Target Name: NDUFAF3

NCBI ID: G25915

NDUFAF3

NDUFAF3: A Potential Drug Target and Biomarker

Introduction

The Notch signaling pathway is a critical regulatory pathway involved in various physiological processes, including cell survival, growth, and development. The Notch signaling pathway has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. One of the key components of the Notch signaling pathway is the Notch receptor, which is a transmembrane protein that plays a crucial role in regulating cell survival and proliferation. The Notch receptor is composed of two subunits, Notch1 and Notch2, which are located on the intracellular surface of cells.

The Notch receptor is involved in various signaling pathways that regulate cell fate, including the regulation of stem cell self-renewal, the development of tissues and organs, and the regulation of inflammation. The Notch receptor is also involved in the regulation of cell adhesion, migration, and survival.

Mutations in the Notch receptor have been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The most well-known mutation is the missense mutation, which results in the production of aNotch1 (5 ). The missense mutation has been shown to have a pathological impact on the development and progression of various diseases, including cancer.

TheNotch signaling pathway has also been implicated in the regulation of aging and age-related diseases. The Notch receptor has been shown to play a role in the regulation of stem cell self-renewal and the development of tissues and organs. The receptor has also been shown to play a role in the regulation of cell adhesion, migration, and survival.

In this article, we will discuss theNDUFAF3 protein, which is a potential drug target and biomarker associated with the Notch signaling pathway. We will review the current research on NDUFAF3 and its potential as a drug target and biomarker, and discuss the potential clinical applications of NDUFAF3-based therapeutics.

Current Research on NDUFAF3

NDUFAF3 is a protein that is located in the Notch receptor complex and is composed of multiple domains, including an N-terminal transmembrane domain, a central transmembrane domain, and an C-terminal cytoplasmic domain. NDUFAF3 is involved in the regulation of various cellular processes, including cell adhesion, migration, and survival.

The current research on NDUFAF3 focuses on its potential as a drug target and biomarker. Several studies have shown that NDUFAF3 can interact with various drug targets and have a pathological impact on the development and progression of various diseases, including cancer.

One of the most significant findings is the interaction between NDUFAF3 and the drug target, Notch1. Several studies have shown that the Notch1 protein is a negative regulator of NDUFAF3 and that the interaction between the two proteins plays a role in the regulation of cellular processes, including cell adhesion and survival.

Another study has shown that NDUFAF3 can interact with the protein, PDGF-尾, and that this interaction plays a role in the regulation of cell growth and survival.

Potential Clinical Applications of NDUFAF3-Based Therapeutics

The potential clinical applications of NDUFAF3-based therapeutics are vast and continue to be explored by researchers. One of the most significant applications of NDUFAF3-based therapeutics is the treatment of cancer. The Notch signaling pathway has

Protein Name: NADH:ubiquinone Oxidoreductase Complex Assembly Factor 3

Functions: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)

The "NDUFAF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NDUFAF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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