NDUFAF5: A Protein of Interest for Cancer and Stem Cell Research

Target Name: NDUFAF5

NCBI ID: G79133

NDUFAF5

NDUFAF5: A Protein of Interest for Cancer and Stem Cell Research

NDUFAF5 (dJ842G6.1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the N-terminal-upregulated gene (NDUFAF) family, which includes several similar proteins that are involved in the regulation of stem cell proliferation and differentiation.

One of the unique features of NDUFAF5 is its ability to interact with several different transcription factors, including NF-kappa-B, NF-kappa-B-containing kinases, and activating transcription factor-3 (ATF-3). This makes it a promising target for the development of new drugs or biomarkers for a variety of diseases.

In addition to its potential as a drug or biomarker, NDUFAF5 is also of interest as a potential therapeutic target for several diseases. For example, it has been shown to be involved in the development and progression of several types of cancer, including neurobladder cancer, melanoma, and colon cancer.

In addition to its potential therapeutic applications, NDUFAF5 is also of interest as a potential research tool for studying the underlying mechanisms of disease. For example, researchers have been able to use RNA sequencing (RNA-seq) to identify differentially expressed genes inNDUFAF5-deficient mouse tissues, which may provide insights into the ways in which the protein is involved in the regulation of gene expression.

Overall, NDUFAF5 is a protein that is widely of interest due to its role in the regulation of stem cell proliferation and differentiation, as well as its potential as a drug or biomarker for a variety of diseases. Further research is needed to fully understand its mechanisms of action and its potential as a therapeutic target.

Protein Name: NADH:ubiquinone Oxidoreductase Complex Assembly Factor 5

Functions: Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable)

The "NDUFAF5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NDUFAF5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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