Trav24: A Potential Drug Target for Many Diseases (G28659)

Target Name: TRAV24

NCBI ID: G28659

TRAV24

Other Name(s): TCRAV24S1 | TCRAV18S1 | T cell receptor alpha variable 24

Trav24: A Potential Drug Target for Many Diseases

Trav24 (TCA24) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Taur family, a calcium channel that regulates ions in cells. The role of channel opening. Trav24 plays an important role in maintaining the ion balance of the cell membrane. However, Trav24 is also involved in the occurrence of some diseases and is therefore considered a potential drug target (or biomarker).

The functions of Trav24 are mainly reflected in the following aspects:

1. Regulate the opening of ion channels: Trav24 is a calcium ion channel, which plays a role in regulating the opening of ion channels in cells. Calcium ions are important intracellular signaling molecules that can regulate many physiological processes, including muscle contraction and nerve impulse transmission. Through the regulatory effect of Trav24, cells can better maintain ion balance and ensure the smooth progress of physiological processes.

2. Participate in cell signaling: Trav24 also plays an important role in cell signaling. Calcium ions serve as a signaling molecule within cells and can participate in many signaling processes. As a calcium ion channel, Trav24 can regulate the opening of ion channels, thereby affecting intracellular signal transduction.

3. Participate in cell metabolism: Trav24 also plays an important role in cell metabolism. Calcium ions play an important metabolic role in cells and can regulate many cellular metabolic processes, including cell proliferation, apoptosis, etc. Through the regulatory effect of Trav24, cells can better maintain metabolic balance and ensure normal cell functions.

4. Participate in cell adhesion: Trav24 also plays an important role in cell adhesion. Calcium ions play an important adhesion role within cells and can help cells adhere to other tissues or cells. Through the regulatory effect of Trav24, cells can better maintain adhesion balance and ensure normal physiological functions.

5. Participate in apoptosis: Trav24 also plays an important role in apoptosis. Calcium ions play an important apoptotic role in cells and can regulate many apoptotic processes. Through the regulatory effect of Trav24, cells can better maintain the balance of apoptosis and ensure normal cell functions.

Trav24 plays an important role in maintaining the ion balance of the cell membrane, participating in cell signaling, participating in cell metabolism, participating in cell adhesion and participating in apoptosis. These functions make Trav24 a potential drug target (or biomarker).

Currently, Trav24 has been shown to be involved in the occurrence of many diseases. For example, studies have found that Trav24 activity is inhibited by certain drugs, including antidepressants, antipsychotics, and antiepileptic drugs. In addition, Trav24 is also related to the occurrence of some diseases, such as neurodegenerative diseases, endocrine disorders, etc.

Therefore, Trav24 is a potential drug target (or biomarker) that can be used to treat many diseases. Future research can delve into the function and mechanism of Trav24 and provide new ideas and methods for the treatment of many diseases.

Protein Name: T Cell Receptor Alpha Variable 24

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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