Trav22: A Protein That Helps Regulate T Cell Development and Immune Response

Target Name: TRAV22

NCBI ID: G28661

TRAV22

Other Name(s): T cell receptor alpha variable 22 | TCRAV13S1 | TCRAV22S1

Trav22: A Protein That Helps Regulate T Cell Development and Immune Response

Trav22 is a protein that is expressed in T cells, a type of white blood cell that plays a crucial role in the immune system. T cells are responsible for detecting and responding to foreign substances in the body, and they are an important part of the immune system because they help to protect the body against infections, viruses, and diseases.

Trav22 is a type of protein that is made up of several different subunits. These subunits include a constant region, a variable region, and an optional C-terminal region. The constant region is the part of the protein that is always present, while the variable region is the part that is different among different copies of the protein. The C-terminal region is the part of the protein that is unique to each copy.

Trav22 is important for the immune system because it helps to stimulate the activity of T cells. When the body encounters a foreign substance that it needs to fight off, the immune system sends a message to the T cells to Activate and begin to divide. This is how T cells are able to recognize and respond to foreign substances in the body.

Trav22 is also important for the development and maintenance of T cell diversity. T cells are able to transform into different types of T cells, each with a different function, and this process is influenced by the Trav22 protein. Trav22 helps to regulate the transformation of T cells into different types, which is important for ensuring that the immune system has a diverse range of capabilities.

In addition to its role in T cell development and maintenance, Trav22 is also important for the regulation of the immune response. When the immune system responds to a foreign substance, Trav22 helps to ensure that the response is appropriate and effective. This is important for protecting the body against infections, viruses, and diseases.

Trav22 is also a potential drug target. Researchers are studying Trav22 to see if it can be used as a new treatment for immune system disorders. For example, some researchers are studying Trav22 to see if it can be used to treat autoimmune diseases, in which the immune system attacks the body's own tissues.

In conclusion, Trav22 is a protein that is important for the immune system. It helps to stimulate the activity of T cells, regulates T cell diversity, and is involved in the regulation of the immune response. Trav22 is also a potential drug target, and researchers are studying it to see if it can be used to treat immune system disorders.

Protein Name: T Cell Receptor Alpha Variable 22

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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