GSTM3: Key Enzyme in Xenobiotic Detoxification and Cellular Signaling

Target Name: GSTM3

NCBI ID: G2947

GSTM3

GSTM3: Key Enzyme in Xenobiotic Detoxification and Cellular Signaling

Glutathione S-aryltransferase M3 (GSTM3) is a gene that encodes a protein known as GSTM3, which is a key enzyme in the detoxification pathway of xenobiotics, such as drugs and environmental toxins. The GSTM3 protein is involved in the transfer of a sulfur group from the xenobiotics to the active site of a glutathione, which is a protein that protects the body against oxidative stress and other harmful substances.

GSTM3 is a member of the GST family of transmembrane proteins, which are involved in the detoxification and neutralization of a wide variety of xenobiotics. The GST family is a large and diverse family that includes over 300 different proteins, many of which are involved in the detoxification of drugs and other harmful substances.

GSTM3 is expressed in many different tissues and cells in the body, including the liver, pancreas, and white blood cells. It is primarily localized to the liver, where it is involved in the detoxification of a wide variety of xenobiotics, including drugs such as chemotherapy drugs, alcohol, and arsenic.

GSTM3 is involved in the transfer of the sulfur group from the xenobiotics to the active site of the glutathione. The sulfur group is a reactive group that can form bonds with a variety of molecules, including other proteins and drugs. The GSTM3 enzyme transfers the sulfur group from the xenobiotics to the active site of the glutathione, which helps to protect the body against oxidative stress and other harmful substances.

GSTM3 is also involved in the regulation of the levels of other proteins in the body. For example, GSTM3 has been shown to regulate the levels of the antioxidant protein NADPH, which helps to protect the body against oxidative stress.

In addition to its role in the detoxification pathway, GSTM3 is also involved in the regulation of inflammation and cellular signaling. For example, GSTM3 has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases such as cancer and autoimmune disorders.

GSTM3 is also involved in the regulation of cellular signaling pathways that are involved in the development and progression of cancer. For example, GSTM3 has been shown to play a role in the regulation of the production of cell cycle proteins, which are involved in the division and growth of cancer cells.

GSTM3 is also involved in the regulation of the transport of nutrients into the body. For example, GSTM3 has been shown to play a role in the transport of toxic compounds from the liver to the rest of the body, which can contribute to the development of toxicity and other health problems.

GSTM3 is a potential drug target and biomarker for a variety of diseases, including cancer, autoimmune disorders, and oxidative stress-related diseases. For example, GSTM3 has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammatory diseases such as cancer and autoimmune disorders. In addition, GSTM3 has been shown to play a role in the regulation of the production of cell cycle proteins, which are involved in the division and growth of cancer cells.

GSTM3 is also involved in the regulation of cellular signaling pathways that are involved in the development and progression of cancer. For example, GSTM3 has been shown to play a role in the regulation of the production of cell cycle proteins, which are involved in the division and growth of cancer cells.

GSTM3 is also involved in the regulation of

Protein Name: Glutathione S-transferase Mu 3

Functions: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers

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