Target Name: GPAT4
NCBI ID: G137964
Review Report on GPAT4 Target / Biomarker Content of Review Report on GPAT4 Target / Biomarker
GPAT4
Other Name(s): 1-AGPAT 6 | GPAT4_HUMAN | Acyl-CoA:glycerol-3-phosphate acyltransferase 4 | glycerol-3-phosphate acyltransferase 6 | Glycerol-3-phosphate acyltransferase 4, transcript variant 1 | testis spermatogenesis apoptosis-related protein 7 | LPAAT-zeta | LPAATZ | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) | 1-acyl-sn-glycerol-3-phosphate acyltransferase zeta | 1-AGP acyltransferase 6 | TSARG7 | lysophosphatidic acid acyltransferase zeta | Glycerol-3-phosphate acyltransferase 4 | Lysophosphatidic acid acyltransferase zeta | GPAT4 variant 1 | Testis spermatogenesis apoptosis-related protein 7 | 1-acylglycerol-3-phosphate O-acyltransferase 6 | glycerol-3-phosphate acyltransferase 4 | Glycerol-3-phosphate acyltransferase 4 (isoform 1) | AGPAT6

GPAT4: A Potential Drug Target for Metabolism, Inflammation and Stress

General Purpose Asset-Based Targets (GPATs) are a family of proteins that play a crucial role in various cellular processes. One of the most well-known GPATs is GPAT4 (1-AGPAT 6), which is a protein that is expressed in various tissues throughout the body. GPAT4 has been identified as a potential drug target and has been shown to be involved in a number of cellular processes, including metabolism, inflammation, and stress.

GPAT4 is a 14kDa protein that is expressed in various tissues, including the brain, heart, liver, and muscle. It is a member of the GPAT family, which includes a number of similar proteins that are involved in the detoxification of xenobiotics and other harmful substances. GPATs are characterized by their ability to bind to and activate the nuclear receptor GBP-伪, which is involved in a number of cellular processes, including metabolism, inflammation, and stress.

One of the most significant functions of GPAT4 is its role in glucose metabolism. GPAT4 is involved in the detoxification of glucose and other simple sugars, and is thought to play a key role in the uptake and storage of these sugars in the liver. This is important for maintaining normal blood sugar levels and for the prevention of diseases such as diabetes, which are characterized by high levels of blood sugar.

In addition to its role in glucose metabolism, GPAT4 is also involved in the detoxification of other harmful substances, including xenobiotics and other environmental toxins. This is important for the prevention of diseases caused by exposure to these substances, such as cancer and neurodegenerative diseases.

GPAT4 is also involved in the regulation of inflammation. Many diseases, including cancer and cardiovascular disease, are characterized by chronic inflammation. GPAT4 is thought to play a key role in the regulation of this inflammation, as it is involved in the detoxification of pro-inflammatory compounds. This is important for the prevention and treatment of these diseases.

In addition to its roles in glucose metabolism, detoxification, and inflammation, GPAT4 is also involved in the regulation of stress. Chronic stress can have a negative impact on both physical and mental health, and GPAT4 is thought to play a key role in the regulation of stress responses. This is important for the prevention and treatment of stress-related diseases, such as anxiety and depression.

As a potential drug target, GPAT4 is an attractive target for researchers because of its involvement in a number of important cellular processes. This makes it an attractive target for the development of new drugs that can treat a variety of diseases, including those related to metabolism, inflammation, stress, and cancer.

In conclusion, GPAT4 is a protein that is expressed in various tissues throughout the body and is involved in a number of important cellular processes. As a potential drug target, GPAT4 is an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of GPAT4 in these processes and to develop new treatments based on this protein.

Protein Name: Glycerol-3-phosphate Acyltransferase 4

Functions: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778). Protects cells against lipotoxicity (PubMed:30846318)

The "GPAT4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPAT4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4