GPAT2: A Potential Drug Target Or Biomarker (G150763)
GPAT2: A Potential Drug Target Or Biomarker
GPAT2 (XGPAT1) is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, diabetes, and neurodegenerative disorders. The gene is located on chromosome 12 and encodes a protein known as GPAT2 (also known as XGPAT1).
GPAT2 is a key regulator of the lipid metabolism, which is the process by which the body produces and uses fat. It is a crucial enzyme in the triacylglycerol (TG) cycle, a central metabolic pathway that generates most of the body's energy. The TG cycle is also known as the \"fat metabolism pathway\" and is involved in the production of fatty acids, which are essential for brain and muscle function, as well as the absorption of nutrients into the body.
GPAT2 is a transcriptional regulator that controls the activity of other genes. It has been shown to regulate the activity of genes involved in cell growth, differentiation, and metabolism. It is also involved in the regulation of inflammation and has been linked to the development of various diseases, including cancer and neurodegenerative disorders.
One of the most promising aspects of GPAT2 is its potential as a drug target. The TG cycle is a key pathway for the production of fatty acids, which are crucial for brain and muscle function. By targeting the TG cycle, drugs can be developed that reduce the production of fatty acids, which can lead to a range of potential therapeutic effects.
GPAT2 has also been shown to be involved in the regulation of inflammation. Chronic inflammation is a major contributor to a range of diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. By targeting GPAT2, researchers may be able to develop new treatments for these diseases.
In addition to its potential as a drug target, GPAT2 is also a potential biomarker for various diseases. The TG cycle is a key pathway for the production of fatty acids, which can be used as a diagnostic marker for diseases that involve alterations in lipid metabolism. GPAT2 may also be used as a biomarker for diseases that are characterized by inflammation, such as cancer and neurodegenerative disorders.
In conclusion, GPAT2 is a gene that has the potential to be a drug target or biomarker for a range of diseases. Further research is needed to fully understand its role in the TG cycle and its potential as a therapeutic or diagnostic agent.
Protein Name: Glycerol-3-phosphate Acyltransferase 2, Mitochondrial
Functions: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity
The "GPAT2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPAT2 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1
