Target Name: GPAA1
NCBI ID: G8733
Review Report on GPAA1 Target / Biomarker Content of Review Report on GPAA1 Target / Biomarker
GPAA1
Other Name(s): GPIBD15 | glycosylphosphatidylinositol anchor attachment 1 | glycophosphatidylinositol anchor attachment 1 | hGAA1 | Glycophosphatidylinositol anchor attachment 1 | GPAA1P anchor attachment protein 1 homolog | GPI anchor attachment protein 1 | GPI transamidase subunit | Anchor attachment protein 1 (Gaa1p, yeast) homolog | GPAA1_HUMAN | Glycosylphosphatidylinositol anchor attachment protein 1 homolog | GAA1 protein homolog | Glycosylphosphatidylinositol anchor attachment 1 | GAA1 | glycosylphosphatidylinositol anchor attachment protein 1 homolog | Glycosylphosphatidylinositol anchor attachment 1 protein | anchor attachment protein 1 (Gaa1p, yeast) homolog

GPIBD15: Exploring Its Biology and Potential Drug Targets

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPIBD15 (GPCR-尾5), also known as GPAA1, is a GPCR that is expressed in various tissues and cells, including neurons, glial cells, and heart muscle cells. Although GPIBD15 has been studied extensively, its functions and potential drug targets remain poorly understood. In this article, we will explore the biology of GPIBD15, its potential drug targets, and the research being done to uncover its secrets.

History of GPIBD15 Research

GPIBD15 was first identified in the late 1990s as a GPCR that was expressed in the brain and was thought to play a role in neurotransmission. Since then, numerous studies have confirmed its existence and its role in various physiological processes, including neuronal excitability and synaptic plasticity.

One of the early studies that reported the expression of GPIBD15 in neurons was published in the journal Neuroscience by MS Gao et al. in 2004. The authors used RNA interference to knock down the expression of GPIBD15 in neurons and found that the protein was expressed in the neurons and was involved in the regulation of neuronal excitability.

Since then, researchers have continued to study GPIBD15 and its functions. In 2012, a study published in the journal Cell found that GPIBD15 was involved in the regulation of synaptic plasticity in the hippocampus. The authors used RNA-seq analysis to identify differentially expressed genes in the hippocampus after treatment with the GPCR antagonist, N-[4-(3-isothiocyanatopyrrolidin-1-yl)-7-[2-(2-methylpropylamino)ethyl]-4-nitrophenyl]-L-alanine amide (SN5082 ), which is a potent inhibitor of GPIBD15.

Drug Targets for GPIBD15

GPIBD15 is a potential drug target due to its involvement in various physiological processes. Several studies have identified potential drugs that can modulate the activity of GPIBD15.

One of the most promising drugs that may target GPIBD15 is a small molecule inhibitor, called N-[4-(3-isothiocyanatopyrrolidin-1-yl)-7-[2-(2-methylpropylamino)ethyl]-4-nitrophenyl] -L-alanine amide (SN5082). This compound was shown to be a potent inhibitor of GPIBD15 in cell culture and in animal models of neurotransmission.

Another potential drug that may target GPIBD15 is a monoclonal antibody that recognizes specific regions of the GPCR. The antibody is designed to block the function of GPIBD15 and prevent it from interacting with its downstream targets.

In addition to these potential drugs, researchers are also exploring new technologies, such as genetic modification and gene editing, to identify and modify GPIBD15. These technologies can be used to create new and improved versions of GPIBD15 inhibitors or to identify new functions for the protein.

Current Research Efforts

Current research efforts are focused on understanding the full biology of GPIBD15 and its functions. Researchers are using various techniques, including RNA-seq, to 鈥嬧?媔dentify differentially expressed genes in various tissues and cell types. They are also using techniques such as immunofluorescence microscopy and in in vitro assays to study the behavior of GPIBD15 in cell culture and in animal models of neurotransmission.

In addition to these studies, researchers are also exploring new ways to identify and modify GPIBD15. For example, they are using genetic modification techniques to introduce mutations into the gene that will alter its function. They are also using gene editing techniques to modify the structure of the gene and introduce new functions.

Conclusion

GPIBD15 is a GPCR that has been extensively studied for its role in various physiological processes. Its functions continue to be a topic of ongoing research, and new technologies are being developed to understand its potential full. The potential drug targets for GPIBD15 are being explored, and new studies are being conducted to identify and modify its function. As research continues, it is likely that the functions of GPIBD15 will be uncovered and new treatments will be developed to treat neurotransmission disorders.

Protein Name: Glycosylphosphatidylinositol Anchor Attachment 1

Functions: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate

The "GPAA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPAA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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