GSTA3: A Potential Drug Target for Neurodegenerative Disorders and Environmental Toxins

Target Name: GSTA3

NCBI ID: G2940

GSTA3

GSTA3: A Potential Drug Target for Neurodegenerative Disorders and Environmental Toxins

Glutathione S-alkyltransferase A3 (GSTA3) is a enzyme that plays a crucial role in the detoxification and metabolism of xenobiotics, such as pesticides and other environmental toxins, in the body. This enzyme is a key target for the development of new drugs for various diseases, including neurodegenerative disorders and autoimmune diseases.

GSTA3 is a member of the superfamily of DNA-binding proteins known as NAD+-dependent enzymes. These enzymes use nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer electrons from the substrate to itself, resulting in the formation of a covalently bound NAD+ derivative. This transfer of electrons creates reactive oxygen species (ROS) that can interact with other molecules and cause oxidative stress in the cell. GSTA3 is involved in the detoxification of xenobiotics by transferring electrons from the toxic molecules to NAD+, which protects the cell from oxidative stress.

GSTA3 is also involved in the metabolism of other molecules, including drugs and other substances that are harmful to the body. Many drugs, including statins, thiopurine drugs, and chemotherapy drugs, can cause oxidative stress in the body by generating ROS. GSTA3 can help to protect the cell from this stress by transferring electrons from the harmful molecules to NAD+.

GSTA3 is a protein that is expressed in many different tissues and cells in the body. It is highest in the brain and testes, and is also found in the liver, spleen, and peripheral blood cells. GSTA3 is involved in the detoxification of xenobiotics and other harmful substances in the body, and is a potential drug target for many diseases.

One of the main potential uses of GSTA3 as a drug target is its role in the detoxification of neurotoxicants. Many neurotoxins, including those that are associated with neurodegenerative disorders, can cause oxidative stress in the brain and contribute to the development of these disorders. GSTA3 can help to protect the brain from this stress by transferring electrons from the neurotoxins to NAD+, which can help to prevent the formation of ROS that can cause oxidative stress.

Another potential use of GSTA3 as a drug target is its role in the detoxification of environmental toxins. Many environmental toxins, including those that are associated with cancer, can cause oxidative stress in the body and contribute to the development of cancer. GSTA3 can help to protect the body from this stress by transferring electrons from the environmental toxins to NAD+, which can help to prevent the formation of ROS that can cause oxidative stress.

In addition to its role in the detoxification of neurotoxins and environmental toxins, GSTA3 is also involved in the metabolism of many other molecules in the body. This makes it a potential drug target for a wide range of diseases, including neurodegenerative disorders, autoimmune diseases, and other conditions that are characterized by oxidative stress in the body.

GSTA3 is a protein that is involved in many different processes in the body. It is expressed in many different tissues and cells, including the brain, testes, liver, spleen, and peripheral blood cells. GSTA3 is involved in the detoxification of xenobiotics and other harmful substances in the body, and is a potential drug target for many diseases. Further research is needed to fully understand the role of GSTA3 in the detoxification of neurotoxins and environmental toxins, and to develop new treatments for diseases that are characterized by oxidative stress in the body.

Protein Name: Glutathione S-transferase Alpha 3

Functions: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity)

The "GSTA3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GSTA3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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