GSK3A: A Non-Catalytic Kinase in Cell Signaling Pathways (G2931)

Target Name: GSK3A

NCBI ID: G2931

GSK3A

GSK3A: A Non-Catalytic Kinase in Cell Signaling Pathways

GSK3A, also known as serine/threonine-protein kinase GSK3A, is a gene that encodes a protein that plays a critical role in cell signaling pathways. The protein is a non-catalytic kinase that is highly expressed in various tissues and cells, including brain, heart, and pancreas. It is known to be involved in the regulation of cell proliferation, differentiation, and survival.

GSK3A is a key regulator of the Wnt signaling pathway, a pathway that plays a crucial role in the development and maintenance of tissues and organs. The Wnt signaling pathway is a complex signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. It is a highly conserved pathway that is involved in the development and maintenance of tissues and organs, including the nervous system, endocrine system, and reproductive system.

GSK3A is a key regulator of the Wnt signaling pathway by participating in the negative regulation of the pathway's activity. It is known to play a critical role in the regulation of cell proliferation and differentiation by inhibiting the activity of the transcription factor SMAD. SMAD is a key regulator of the Wnt signaling pathway and is involved in the regulation of cell proliferation and differentiation.

GSK3A is also involved in the regulation of cell survival and stress resistance. It is known to play a critical role in the regulation of cell survival by activating the protein Bcl-2. Bcl-2 is a protein that is known to play a critical role in the regulation of cell survival and stress resistance.

GSK3A is also involved in the regulation of cell signaling pathways that are involved in inflammation and immune response. It is known to play a critical role in the regulation of the NF-kappa-B signaling pathway, a pathway that is involved in inflammation and immune response.

GSK3A is a potential drug target and a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. It is known to play a critical role in the regulation of cell signaling pathways that are involved in the development and maintenance of tissues and organs, including the nervous system, endocrine system, and reproductive system.

In conclusion, GSK3A is a gene that encodes a protein that plays a critical role in cell signaling pathways. It is a non-catalytic kinase that is highly expressed in various tissues and cells, including brain, heart, and pancreas. It is known to be involved in the regulation of cell proliferation, differentiation, and survival, as well as the regulation of cell signaling pathways that are involved in inflammation and immune response. As a potential drug target and biomarker, GSK3A is a promising target for the development of new treatments for various diseases.

Protein Name: Glycogen Synthase Kinase 3 Alpha

Functions: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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