GSDME: A Drug Target / Disease Biomarker (G1687)

Target Name: GSDME

NCBI ID: G1687

GSDME

GSDME: A Drug Target / Disease Biomarker

GSDME (Gastrin-Releasing Secretory Mucin) is a protein that is expressed in various body tissues and is involved in the production of gastrin, a hormone that regulates the functions of the digestive system. GSDME has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, GSDME has potential as a drug target or biomarker for a variety of diseases.

GSDME is a 23-kDa protein that is expressed in the epithelial cells of the small intestine, pancreatic duct, and salivary glands. It is composed of a 165 amino acid protein that consists of a catalytic region, a transmembrane region, and an intracellular region. The catalytic region contains a GSDME-specific catalytic domain that is responsible for the protein's catalytic activity.

GSDME is involved in the production of gastrin, which is a hormone that plays a critical role in the regulation of the digestive system. Gastrin is produced by the cells of the parietal cell, which is located in the lining of the small intestine. The parietal cell consists of a cAMP-dependent secretory pathway that is responsible for the production of gastrin.

In addition to its role in the production of gastrin, GSDME is also involved in the regulation of the secretion of other hormones and enzymes in the digestive system. For example, GSDME has been shown to play a role in the production of bicarbonate, which is a critical regulator of carbonate homeostasis. Bicarbonate is produced by the cells of the epithelial layer of the small intestine and is responsible for maintaining the proper pH of the lumen.

GSDME is also involved in the regulation of the production of other hormones and enzymes in the digestive system. For example, GSDME has been shown to play a role in the production of mucinases, which are enzymes that are responsible for the production of mucin, a component of the extracellular matrix. Mucinases are produced by the cells of the epithelial layer of the small intestine and are involved in the regulation of various physiological processes in the digestive system.

In addition to its role in the production of hormones and enzymes, GSDME is also involved in the regulation of cellular processes in the digestive system. For example, GSDME has been shown to play a role in the regulation of cytoskeletal organization and cell adhesion. GSDME is expressed in the epithelial cells of the small intestine and is involved in the regulation of the cytoskeleton organization, which is critical for the proper functioning of the cell.

GSDME is also involved in the regulation of the production of other proteins in the digestive system. For example, GSDME has been shown to play a role in the production of secretin, which is a hormone that is responsible for the regulation of various physiological processes in the digestive system. Secretin is produced by the cells of the parietal cell and is involved in the regulation of various physiological processes in the digestive system, including the secretion of bicarbonate.

In addition to its role in the production of hormones and proteins, GSDME is also involved in the regulation of cellular processes in the digestive system. For example, GSDME has been shown to play a role in the regulation of apoptosis, which is a process that is responsible for the programmed cell death. GSDME is expressed in the epithelial cells of the small intestine and is involved in the regulation of apoptosis, which is critical for the proper functioning of the cell.

GSDME is also involved in the regulation of the production of other proteins in the digestive system. For example, GSDME has been shown to play a role in the production oflandsdiuretic, which is a hormone that is responsible for the regulation of water and electrolyte balance. Landsdiuretic is produced by the cells of the parietal cell and is involved in the regulation of various physiological processes in the digestive system, including the regulation of blood pressure.

In addition to its role in the production of hormones and proteins, GSDME is also involved in

Protein Name: Gasdermin E

Functions: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430)

The "GSDME Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GSDME comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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