GSTA1 Gene as Potential Drug Target for Various Diseases (G2938)

Target Name: GSTA1

NCBI ID: G2938

GSTA1

GSTA1 Gene as Potential Drug Target for Various Diseases

Glutathione S-aryltransferase A1 (GSTA1) is a gene that encodes a protein located in the endoplasmic reticulum (ER) and known for its role in the production of glutathione, a naturally occurring antioxidant that protects the body from oxidative stress. The GSTA1 gene has has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

GSTA1 is a member of the GST family, which includes a variety of enzymes involved in the detoxification of xenobiotics and other harmful substances. The GSTA1 enzyme is responsible for the conversion of a specific metabolite, 2-phenyl-1-propanethiol (2-PP ), into its active form, 2-phenyl-1-propanethiol dehydrogenase (2-PPDEH). 2-PPDEH is a key enzyme in the production of glutathione, which is a naturally occurring antioxidant that protects the body from oxidative stress caused by free radicals.

Glutathione is a powerful antioxidant that neutralizes free radicals, which are unstable molecules that can cause damage to cells and contribute to the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Causes cell damage and contributes to the development of a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Glutathione exerts antioxidant effects in the body, protecting the body from the damage of oxidative stress by neutralizing free radicals.

The protein encoded by the GSTA1 gene is a protein with a molecular weight of 41.1 kDa, which plays important biological functions in cells. Research shows that GSTA1 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases and autoimmune diseases. The protein encoded by the GSTA1 gene is a protein with a molecular weight of 41.1 kDa, which plays important biological functions in cells. Research shows that GSTA1 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases and autoimmune diseases.

Variations in the GSTA1 gene are associated with the occurrence of various diseases. For example, variations in the GSTA1 gene are associated with neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In addition, variations in the GSTA1 gene are also associated with the occurrence of cancer. For example, variations in the GSTA1 gene are associated with cancers such as lung cancer, colorectal cancer, and breast cancer. Variations in the GSTA1 gene are associated with the occurrence of various diseases. For example, variations in the GSTA1 gene are associated with neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In addition, variations in the GSTA1 gene are also associated with the occurrence of cancer. For example, variations in the GSTA1 gene are associated with cancers such as lung cancer, colorectal cancer, and breast cancer.

Currently, researchers are exploring the potential role of the GSTA1 gene in treating various diseases. For example, researchers are studying whether the GSTA1 gene could serve as a new target for treating neurodegenerative diseases. In addition, researchers also found that the GSTA1 gene can be used as a potential target for the treatment of certain cancers. The GSTA1 gene has potential role in the treatment of various diseases. For example, researchers are studying whether the GSTA1 gene could serve as a new target for treating neurodegenerative diseases. In addition, researchers also found that the GSTA1 gene can be used as a potential target for the treatment of certain cancers.

In short, the GSTA1 gene is an important gene that plays important biological functions in the body and plays a key role in the occurrence of various diseases. Currently, researchers are exploring the potential role of the GSTA1 gene in the treatment of various diseases and working hard to develop the GSTA1 gene as a new drug target to treat various diseases. The GSTA1 gene is an important gene that plays important biological functions in the body and plays a key role in the occurrence of various diseases. Currently, researchers are exploring the potential role of the GSTA1 gene in the treatment of various diseases and working hard to develop the GSTA1 gene as a new drug target to treat various diseases.

Protein Name: Glutathione S-transferase Alpha 1

Functions: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487)

The "GSTA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GSTA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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