Target Name: RNASE1
NCBI ID: G6035
Review Report on RNASE1 Target / Biomarker Content of Review Report on RNASE1 Target / Biomarker
RNASE1
Other Name(s): ribonuclease, RNase A family, 1 (pancreatic) | RAC1 | RNase 1 | Ribonuclease A family member 1, pancreatic, transcript variant 4 | RNASE1 variant 4 | Ribonuclease pancreatic | RNAS1_HUMAN | RNase A | RIB1 | ribonuclease A family member 1, pancreatic | ribonuclease 1 | Ribonuclease A | RNS1 | RNASE1 variant 1 | RNase upI-1 | Ribonuclease A family member 1, pancreatic, transcript variant 1 | Ribonuclease 1 | ribonuclease A C1 | RNase UpI-1 | HP-RNase | RIB-1

Understanding RNase A: A Potential Drug Target for Cancer

Ribonuclease (RNase) A, also known as RNase A1, is a member of the RNase A family that is expressed in various tissues throughout the body, including pancreatic ductal cells, pancreatic acinar cells, and peritoneal cavity. It is a 43kDa single-stranded RNA enzyme that is involved in the processing of double-stranded RNA is sheared into single-stranded RNA, which is mainly guided by RNA in the nucleus. It hydrolyzes nucleic acids in the cell, mainly acting on the 5' end of RNA.

RNase A plays an important role in organisms, such as regulating gene expression, degrading invading pathogens such as viruses and bacteria, and maintaining cellular homeostasis. However, abnormal RNase A expression levels may also lead to the occurrence of various diseases, so the study of RNase A has important clinical significance.

Currently, RNase A has become a key target of many drug studies because it has a high expression level and is up-regulated in a variety of cancers, such as lung cancer, liver cancer, breast cancer, etc. Many studies have explored the possibility of using RNase A as a drug target to treat these cancers, but because RNase A is expressed at low levels in various tissues, finding effective therapeutic targets remains a challenge.

Nonetheless, several studies have identified RNase A's potential as a drug target and some compounds with potential. For example, studies have found that inhibition of RNase A has potential as a new therapeutic approach for pancreatic cancer, due to its high expression level in pancreatic ductal cells and its involvement in the regulation of pancreatic cancer cell growth and metastasis. In addition, some studies have also found , the expression level of RNase A can be used as a biomarker to predict the survival of patients with pancreatic cancer.

In addition, some studies have also explored the mechanism of using RNase A to regulate gene expression and discovered the importance of its interaction with RNA-binding proteins (RBPs).

Protein Name: Ribonuclease A Family Member 1, Pancreatic

Functions: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA

The "RNASE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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